Lactobacillus Fermentum

Lactobacillus Fermentum

Lactobacillus fermentum (Lb. fermentum) is a Gram-positive bacterium that belongs to the Lactobacillus genus. It is said to boost the immune system and prevent gastrointestinal and upper respiratory infections that people get from other people.

You can also get Lactobacillus through your diet, so try these five foods:

  • Yoghurt. Read what it says.
  • Sauerkraut. This fermented cabbage dish has many strains of Lactobacillus, which are good bacteria.
  • Kefir.
  • Bread made with sourdough starter.
  • Kimchi.

Lactobacillus fermentum is one of the most common types of bacteria found in natural whey cultures for hard “pasta filata” cheeses like Caciocavallo Silano and Parmigiano Reggiano. Lactobacillus fermentum belongs to the group of Lb. reuteri.

Lactobacillus fermentum, an organism that has been linked to cholecystitis.

Possible Side Effects

Some of the most common side effects are stomach problems like gas, bloating, upset stomach, or diarrhoea. Most digestive side effects get better with time, but if they don’t get better or get worse, you should stop taking L.

L. fermentum is one of the less-studied probiotic strains, but early clinical studies on cholesterol and immunity have shown that it may be helpful. Find out more here.

What is lactic acid bacteria?

Lactobacillus fermentum is a Gram-positive lactic acid bacterium that is often found in animal and plant matter that is fermenting. It is also often found as a part of the microbiota of humans.

L. fermentum exhibits significant antioxidant properties

L. fermentum is good for your health.

L. fermentum probiotic supplements are not approved by the FDA for medical use, and there isn’t a lot of good clinical research on them in general.

Standards for making them are set by regulations, but that doesn’t mean they’re safe or effective. Talk to your doctor before taking any supplements.

There isn’t enough proof for

Only a few, low-quality clinical studies back up the following supposed benefits. There isn’t enough evidence to show that L. fermentum can be used for any of the things listed below.
Talk to your doctor before taking probiotic supplements, and never use them instead of something your doctor recommends or prescribes.

1) Cholesterol: In a clinical study of 46 people, L. fermentum helped cholesterol a little bit.

L. fermentum lowered the amount of total cholesterol, total triglycerides, and LDL cholesterol in mice. It also made the body weigh less and the ratio of liver weight to body weight go down.

2) Defense

L. fermentum cut the length and severity of respiratory illnesses in runners who ran long distances.

L. fermentum made stomach and lung illness symptoms less severe in male cyclists, but not in female cyclists.

L. fermentum helped keep babies from getting stomach and upper respiratory tract infections.

L. fermentum also eases pain and lowers the amount of Staphylococcus in the breastmilk of women who have trouble nursing.

Animal & Cell Research (Lacking Evidence)

There is no clinical evidence that L. fermentum is helpful for any of the conditions listed in this section.

Here is a summary of the animal and cell-based research that has already been done, which should help guide future research. But the studies listed below shouldn’t be taken as proof that anything is good for your health.

3) Nutrient Bioavailability

It has been shown that L. fermentum makes calcium, phosphorus, and zinc more bioavailable in fermented goat milk.

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4) Getting hurt

In lab tests, both living and dead L. fermentum were shown to slow down the inflammatory process and reduce inflammatory mediators.

L. fermentum can make mice’s upper small intestines less inflamed.

L. fermentum reduces the amount of inflammation in rats with colitis.

5) Lactose Intolerance

L. fermentum breaks down S1-casein and makes it harder for IgE in the blood of people with cow’s milk allergy to recognise and bind to this casein.

6) Healthy Gut

L. fermentum increases Lactobacillus, Bifidobacterium and Eubacterium levels in mice

L. fermentum brings the gut microbiota back to normal and reduces inflammation in the colon caused by ampicillin in mice.

L. fermentum alleviates constipation in mice

L. fermentum makes it better for mice whose stomachs were hurt by ethanol.

L. fermentum helps mice and rats with colitis feel better and get better faster.

7) Mood and the way the brain works

L. fermentum helps mice act less anxious and remember things better after ampicillin has hurt their memories.

8) Liver Damage

L. fermentum helps alcoholic liver disease mice with liver damage a lot.

Green tea extract and L. fermentum keep ethanol from damaging liver cells.

A traditional herbal medicine called Ssanghwa-tang (SHT) protects the liver of rats. L. fermentum makes this effect even stronger.

9) Getting sick

Viruses L. fermentum make mice and chickens less likely to die from a lethal flu infection by turning on the Th1 response and making more IgA.

When given by mouth, L. fermentum boosts the immune response to an anti-flu vaccine and may improve systemic protection by increasing the Th1 response and antibodies that fight viruses.

People who took this probiotic were less likely to get a flu-like illness 5 months after getting vaccinated.

Bacteria & Fungi

L. fermentum stops the growth of staphylococci, enterotoxigenic enterobacteria, and Candida albicans. It has been shown to fight S. aureus and P. aeruginosa, which are common causes of hospital-acquired infections.

Streptococcus pneumoniae, Pseudomonas aeruginosa, Salmonella, and S. typhimurium infections in mice can all be fought off by L. fermentum.

In the lab, L. fermentum stops both C. albicans and C. glabrata, which are the two most common yeasts that make people sick.

Aging & Immunity

L. fermentum helps fight immunosenescence by increasing the activity of antioxidant enzymes. It has also been shown to reduce E. coli infections in older mice.

How something works

Cell and animal studies have been used to look into how L. fermentum might work to help people. They’ve found that this probiotic:

antioxidant enzymes like superoxide dismutase, catalase, and glutathione peroxidase worked better.
IgG2a response was stronger than IgG1, which shows a Th1-biased humoral response.

IgA went up, and IgE went down.

The number of natural killer (NK) cells has gone up.

IFN- levels went up (a study where it was decreased: ).

IL-2 went up and IL-6 and IL-8 went down.

IL-4 has both gone up and down.

Both made IL-10 go up and both made it go down.

IL-1, TNF-, and iNOS all went down.

Rac, p38, and NF-kappaB activation went down.

Occludin, EGF, EGFR, VEGF, Fit-1, IB-, nNOS, eNOS, Mn-SOD, Cu/Zn-SOD, and CAT all went up.

PGE2 got higher.

boosted mucosal immunity, perhaps by making tracheal lymphocytes multiply and lung macrophages grow in number.

After treatment with ampicillin, there were more mineralocorticoid and N-methyl-D-aspartate receptors in the hippocampus.


L. fermentum is often found in fermented foods, and the US FDA says that it is an organism that is “generally recognised as safe” (GRAS). It was proven to be safe for babies and kids.

But in people who don’t have strong immune systems, it can lead to bacteremia. Probiotics shouldn’t be given to people who have organ failure, a weakened immune system, or gut barrier mechanisms that don’t work right.

A strain of L. fermentum called AGR1487 makes the host more inflamed and should be avoided.

Before taking L. fermentum probiotics, you should talk to your doctor to make sure they won’t hurt you or cause problems.