Obesity is a chronic, relapsing, progressive disease.
When the body mass index (BMI) exceeds 25 kg/m2, it is characterised by abnormal and excessive fat buildup.
1 Numerous medical, surgical, gynaecological, obstetric, social, and psychological diseases include hypertension, cancer, cerebrovascular accidents, hyperlipidemia, coronary heart disease, diabetes mellitus, and degenerative arthritis are among the numerous health concerns associated with obesity. 2 Therefore, obesity has a significant financial impact.
Changes in lifestyle, exercise, food therapy, medications with anti-lipase inhibitory actions, or medicinal plants are some strategies for overcoming obesity. However, the gut microbiota is a crucial role in the relationship between obesity and metabolic diseases. Obesity, type 2 diabetes, cardiovascular illnesses, and non-alcoholic fatty liver disease are all linked to the gut microbiota. 3 The inflammation of adipose tissue and obesity are related to the high proportion of intestinal firmicutes and the low proportion of Bacteroides.
4 Compared to firmicutes, bacteroides have fewer enzyme genes for lipid and carbohydrate metabolism, which lowers their ability to absorb energy from food.
5 Probiotics, which are live, healthy bacteria, are a promising way to change the microbiota in the stomach.
6 The probiotic recognised as the weight loss probiotic is Lactobacillus gasseri.
The effectiveness of L. gasseri for weight loss is discussed in this review article. lactic acid bacteria An indigenous human intestine bacterium called Lactobacillus gasseri is acid resistant, bile tolerant, and distinguishable from L. acidophilus by typical phenotypic traits. Compared to L. acidophillus, L. gasseri L-LDH has a distinct cell wall composition and electrophoretic mobility.
7Cardiolipin, a membrane phospholipid of L. gasseri JCM1131, is crucial to the ability of bacteria to resist bile acids.
L. gasseri produces inulin, poly-oligosaccharides, and a variety of fructo-oligosaccharides.
9 Inulosucrase from L. gasseri DSM 20604 is used to produce inulin from sucrose.
10Lactobacillus gasseri binds to intestinal tissue, inhibits faecal mutagenic enzyme production, and activates macrophages in the intestine.
It has antibacterial properties and can stick to Caco-2 cells. In rats, it decreased bile acids, triglycerides, serum total cholesterol, LDL cholesterol, and faecal coliforms. While fully neutral steroids were unaffected by L. gasseri in hypercholesterolemic rats, the amounts of acidic steroids rose in faeces. 11 Probiotic microorganisms are suggested to reduce serum cholesterol in two separate ways. By inhibiting bile acid reabsorption into the enterohepatic circulation, L. gasseri is able to increase the excretion of acidic steroids in faeces. Additionally, dietary fibre increases faeces excretion by adhering to the surface of the intestine and deconjugating bile acids with limited absorption from the small intestine. Bile acids that have been deconjugated are harmful to the development of coliform or pathogenic bacteria. 12 Gasse, L.