Capsaicin comes from red peppers. Substance P, a neurotransmitter responsible for pain, is the primary target of this treatment. There are no notable safety concerns, and randomised controlled trials evaluating its use in treating osteoarthritis have shown that it can be beneficial in lowering pain and tenderness in affected joints. Single trial evidence suggests it may be helpful for fibromyalgia.


Natural remedies derived from hot peppers (Capsicum family)
Capsaicin, the chemical name,
Axsain, Zacin, chilli, pepper gel, cayenne, and a few other names.
Capsaicin, extracted from chilli peppers, is the plant’s primary medicinally active component. Products such as gels, creams, and plasters are available in the UK with a doctor’s prescription for the treatment of osteoarthritis.

How does it function, exactly?

Numerous scientific investigations have established that capsaicin can deplete levels of Substance P. You can thank substance P for the fact that your brain is now aware of your pain. There is evidence that it also plays a role in the activation of inflammatory chemicals in the joints.

How secure is it?

The topical use of capsaicin gel or cream has no significant health risks. When the gel comes into contact with your skin, you could feel a burning sensation. For this reason, capsaicin causes a burning sensation without causing any actual tissue damage by binding to particular receptors in nerve endings termed VR1. Capsaicin can produce skin blisters at high concentrations, although usually only after it has caused temporary redness.

Surrounding one third of persons report a reaction around the area where the medication is given, according to an evaluation of capsaicin applied to the skin to treat chronic pain (not especially related to osteoarthritis, rheumatoid arthritis, or fibromyalgia).

Keep capsaicin away from your eyes, mouth, and any cuts or scrapes you may have. As far as we know, there are no negative medication interactions.

In most studies, researchers have applied capsaicin gel with a concentration of 0.025% or 0.075% to the skin four times daily.